Nanostructured Oxygen Sensor - Using Micelles to Incorporate a Hydrophobic Platinum Porphyrin
نویسندگان
چکیده
Hydrophobic platinum(II)-5,10,15,20-tetrakis-(2,3,4,5,6-pentafluorophenyl)-porphyrin (PtTFPP) was physically incorporated into micelles formed from poly(ε-caprolactone)-block-poly(ethylene glycol) to enable the application of PtTFPP in aqueous solution. Micelles were characterized using dynamic light scattering (DLS) and atomic force microscopy (AFM) to show an average diameter of about 140 nm. PtTFPP showed higher quantum efficiency in micellar solution than in tetrahydrofuran (THF) and dichloromethane (CH₂Cl₂). PtTFPP in micelles also exhibited higher photostability than that of PtTFPP suspended in water. PtTFPP in micelles exhibited good oxygen sensitivity and response time. This study provided an efficient approach to enable the application of hydrophobic oxygen sensors in a biological environment.
منابع مشابه
Platinum Nanoparticle Electrode Modified Iodine using Cyclic Voltammetry and Chronoamperometry for Determination of Ascorbic Acid
This study investigated the oxidation of ascorbic acid (Vitamin C) using a platinum nanoparticle electrode coated with an iodine monolayer, called a modified electrode. The electrode were grown using the cyclic voltammetry technique and the electrochemical measurements were taken using the cyclic voltammetry and chronoamperometric technique. In the case of platinum nanoparticle electrode modifi...
متن کاملAblation of Hypoxic Tumors with Dose-Equivalent Photothermal, but Not Photodynamic, Therapy Using a Nanostructured Porphyrin Assembly
Tumor hypoxia is increasingly being recognized as a characteristic feature of solid tumors and significantly complicates many treatments based on radio-, chemo-, and phototherapies. While photodynamic therapy (PDT) is based on photosensitizer interactions with diffused oxygen, photothermal therapy (PTT) has emerged as a new phototherapy that is predicted to be independent of oxygen levels withi...
متن کاملA comparative study of the interaction of platinum with group 4A (germanium, tin and lead) porphyrins.
Because of its vast number of applications and high price many studies have been made on how to reduce the amount of platinum in catalysts. One method includes dispersing platinum nanoparticles in porous support materials. But electrically conductive carbon-based support materials-needed for fuel cell electrodes-permit nanoparticles to migrate and form larger clusters, leading to reduced cataly...
متن کاملNovel nanostructured materials to develop oxygen-sensitive films for optical sensors
Novel nanostructured materials, such as aluminum oxide (AlOOH), silicon oxide (SiO2) or zirconium oxide (ZrO2) embedded into PVA, were investigated as potential matrices to incorporate organometallic compounds (OMCs) for the development of optical oxygen-sensitive sensors which make use of the principle of luminescence quenching.
متن کاملDevelopment of polymeric nanoprobes with improved lifetime dynamic range and stability for intracellular oxygen sensing.
A class of core-shell nanoparticles possessing a layer of biocompatible shell and hydrophobic core with embedded oxygen-sensitive platinum-porphyrin (PtTFPP) dyes is developed via a radical-initiated microemulsion co-polymerization strategy. The influences of host matrices and the PtTFPP incorporation manner on the photophysical properties and the oxygen-sensing performance of the nanoparticles...
متن کامل